Laboratory of Advanced Microfluidic Systems

 
  PUBLICATIONS  
  Manuscripts in Preparation  
 


On-Going

  1. Shuhuan Hu, and Raymond H. W. Lam, "Cell Spreading", in preparation.
  2. Dinglong Hu, Xin Yao, Marcos, and Raymond H. W. Lam, "Aggregation of Floating Cells along Flows", in preparation.
  3. Dinglong Hu*, Josh H. M. Lam*, Chung Tin, and Raymond H. W. Lam, "An Automated Cell Manipulation Platform Based on Microflow Control for Patterned Cell analysis Applications", in preparation.
  4. Yohannes L. Yaphary, Shuhuan Hu, Zechuan Yu, Denvid Lau, and Raymond H. W. Lam, "Piezoelectricity of Electrostatically Hydrated Portland Cement", in preparation.
  5. Shuhuan Hu, "Intracellular Biophysical Properties", in preparation.
  6. Xin Cui, Tom T. Y. Wu, and Raymond H. W. Lam, "Review on Microfluidic Platforms for Vascular Research", in preparation.
  7. Weiqiang Chen, Steven G. Allen, Shuo Han, Xiang Li, Chelsea Fournier, Yubing Sun, Liwei Bao, Raymond H. W. Lam, Sofia D. Merajver, and Jianping Fu, "Functional and Biophysical Phenotyping of Inflammatory Breast Cancer Stem Cells", in preparation.
  8. Chengpeng Yang et al., Biopotential Signal Transmission in a Defined Neuronal Network, in preparation.
  9. Baoce Sun et al., "Cell Alignment Mediated by Micro- and Nano-topography", in preparation.
  10. Dinglong Hu et al., "A Metastasis Model", in preparation.
  11. Ya Liu et al., "Immune Cell Characterization", in prepartion.

Submitted / To be Submitted

  1. Xin Cui*, Ya Liu*, Dinglong Hu, Weiyi Qian, Chung Tin, Dong Sun, Weiqiang Chen, and Raymond H. W. Lam, "Probing the Cell Signaling Molecule Dynamics Assisted by Precise Microfluidic Mixing", submitted.
  2. Chengpeng Yang*, Vincent W. T. Li*, Chung Tin, Peter K. N. Yu, S. H. Cheng, and Raymond H. W. Lam, "Enhanced Alpha Radiation Quantification Based on Radio-Amperometric Activity of Genetically Modifed Bactera Using Microfluidic Electrokinectic Focusing", to be submitted.
  3. Baoce Sun, Kai Xie, Shuhuan Hu, Denvid Lau, and Raymond H. W. Lam, "Correlation between Subcellular Contractility and Phenotypic Attachment of Vascular Endothelial Cells", to be submitted.
  4. Xin Cui, Ting-Hsuan Chen, Dong Sun and Raymond H. W. Lam, "Nucleus Reorientation Guided by Subcellular Cytoskeleton Architectures", to be submitted.
  5. Ya Liu, Dong Sun and Raymond H. W. Lam, "A Microfluidic Cell Isolation and Extraction Platform for Drug Screening Applicatons", to be submitted.
  6. Shuhuan Hu and Raymond H. W. Lam, "Revealing Biophysical Properties of Floating Cells Based on the Nonlinear Tatara Model", to be submitted.
 
  Journal Publications (* Authors equally contributed.)  
 


2017

  1. Shuhuan Hu, and Raymond H. W. Lam, "Characterization of Viscoelastic Properties of Normal and Cancerous Human Breast Cells Using a Confining Microchannel", Microfluidics and Nanofluidics, vol. 21, 68, 2017. (DOI: 10.1007/s10404-017-1903-x)
    [Link] [pdf]
  2. Xin Cui, Weijin Guo, Yubing Sun, Baoce Sun, Shuhuan Hu, Dong Sun, and Raymond H. W. Lam, "A Microfluidic Device for Isolation and Characterization of Transendothelial Migrating Cancer Cells", Biomicrofluidics, vol. 11(1), 014105, 2017. (DOI: 10.1063/1.4974012)
    [Link] [pdf]
  3. Baoce Sun, Kai Xie, Ting-Husuan Chen, and Raymond H. W. Lam, "Preferred Cell Alignment along Concave Microgrooves", RSC Advances, vol. 7, pp. 6788-6794, 2017. (DOI: 10.1039/C6RA26545F)
    [Link] [pdf]
  4. Ka I Au Ieong*, Chengpeng Yang*, Chin To Wong, Angelie C. Shui, Tom T. Y. Wu, Ting-Hsuan Chen and Raymond H. W. Lam, "Microfluidic Drug Toxicity Assay for Cancer Cell Clusters", Micromachines, vol. 8, 167, 2017. (DOI: 10.3390/mi8060167)
    [Link] [pdf]
  5. Yohannes L. Yaphary*, Zechuan Yu*, Raymond H. W. Lam, and Denvid Lau, "Effect of Triethanolamine on Cement Hydration towards Initial Setting Time", Construction & Building Materials, vol. 141, pp.94-103, 2017. (DOI: 10.1016/j.conbuildmat.2017.02.072)
    [Link] [pdf]
  6. Yohannes L. Yaphary, Raymond H. W. Lam, and Denvid Lau, "Chemical Technologies for Modern Concrete Production", Procedia Engineering, vol. 172, pp. 1270-1277, 2017. (DOI: 10.1016/j.proeng.2017.02.150)
    [Link] [pdf]
  7. Yohannes L. Yaphary, Zechuan Yu, Raymond H. W. Lam, David Hui, and Denvid Lau, "Molecular Dynamics Simulations on Adhesion of Epoxy-Silica Interface in Salt Environment", revision submitted to Composites Part B: Engineering, 2017.
    [Link] [pdf]
  8. Shuhuan Hu, Ting-Hsuan Chen, Yanhua Zhao, Zuankai Wang, and Raymond H. W. Lam, "Convalently Coated Extracellular Matrix Protein Micropatterns for Cell Migration Analysis", revision submitted to Biofabrication, 2017.
    [Link] [pdf]
  9. Xin Cui, Weiqiang Chen, Dong Sun, and Raymond H. W. Lam, "Subcellular Cytoskeleton Architectures and Dynamics Regulates Cell Migration Behaviors", revision submitted.
    [Link] [pdf]

2016

  1. Wei Liu, Yuanye Bao, Miu Ling Lam, Ting Xu, Kai Xie, Hin Sum Man, Edward Y. Chan, Ninghao Zhu, Raymond H. W. Lam, and Ting-Hsuan Chen, "Nanowire Magnetoscope Reveals a Cellular Torque with Left–Right Bias", ACS Nano, vol. 10(8), pp 7409–7417, 2016. (DOI: 10.1021/acsnano.6b01142)
    [Link] [pdf]
  2. T. D. Quang, T. F. Kong, Dinglong Hu, Marcos, and Raymond H. W. Lam, "Deterministic Sequential Isolation of Floating Cancer Cells under Continuous Flow", Lab on a Chip, vol. 16(15), pp. 2813-2819, 2016. (DOI: 10.1039/C6LC00615A)
    [Link] [pdf]
    - Selected as the inside back cover image.

  3. Yuanye Bao, Yaozhun Huang, Miu Ling Lam, Ting Xu, Ninghao Zhu, Zhaobin Guo, Xin Cui, Raymond H. W. Lam and Ting-Hsuan Chen, "Substrate Stiffness Regulates the Development of Left-Right Asymmetry in Cell Orientation", ACS Applied Materials & Interfaces, vo. 8(28), pp. 17976-17986, 2016. (DOI: 10.1021/acsami.6b06789)
    [Link] [pdf]
  4. Raymond H. W. Lam, Xin Cui, Weijin Guo, and Todd Thorsen, "High-Throughput Dental Biofilm Growth Analysis for Multiparametric Microenvironmental Biochemical Conditions Using Microfluidics", Lab on a Chip, vol. 16(9), pp. 1652-1662, 2016. (DOI: 10.1039/C6LC00072J)
    [Link] [pdf]
  5. Shuhuan Hu, Guangyu Liu, Weiqiang Chen, Xiang Li, Wei Lu, Raymond H. W. Lam, and Jianping Fu, "Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using Elasticity Microcytometer", Small, vol. 12(17), pp. 2300-2311, 2016. (DOI: 10.1002/smll.201503620)
    [Link] [pdf]
    - Selected as the front cover image.

  6. Vincent W. T. Li, Mei Po M. Tsui, Xueping Chen, Michelle N. Y. Hui, Ling Jin, Raymond H. W. Lam, Richard M. K. Yu, Margaret B. Murphy, Jingping Cheng, Paul K. S. Lam, and Shuk Han Cheng, "Effects of 4-methylbenzylidene Camphor (4-mbc) on Neuronal and Muscular Development in Zebrafish (danio rerio) Embryos". Environmental Science and Pollution Research, vol. 23(9), pp. 8275-8285, 2016. (DOI: 10.1007/s11356-016-6180-9)
    [Link] [pdf]

2015

  1. Chengpeng Yang*, Dinglong Hu*, Baoce Sun, Qian Zhu, Xin Cui, and Raymond H. W. Lam, "Mechanical Mixing in an Enclosed Microfluidic Chamber through Moving Boundary Motions", Microfluidics and Nanofluidics, vol. 17(3), pp. 711-720, 2015. (DOI: 10.1007/s10404-015-1596-y)
    [Link] [pdf]
  2. Dinglong Hu*, Tin Kei Cheng*, Kai Xie, and Raymond H. W. Lam, "Microengineered Conductive Elastomeric Electrodes for Long-Term Electrophysiological Measurements with Consistent Impedance under Stretch", Sensors, 15(10), pp. 26906-26920, 2015. (DOI: 10.3390/s151026906)
    [Link] [pdf]

2014

  1. Xin Cui, Hon Ming Yip, Qian Zhu, Chengpeng Yang, and Raymond H. W. Lam, "Microfluidic Long-Term Differential Oxygenation for Bacteria Growth Characteristics Analyses", RSC Advances, vol. 4(32), pp. 16662-16673, 2014. (DOI: 10.1039/C4RA01577K)
    [Link] [pdf]
  2. Hon Ming Yip, John C. S. Li, Kai Xie, Xin Cui, Agrim Prasad, Qiannan Gao, Chi Chiu Leung, and Raymond H. W. Lam, "Automated Long-Term Monitoring of Parallel Microfluidic Operations Applying a Machine Vision-Assisted Positioning Method", Scientific World Journal, vol. 2014, 2014. (DOI: 10.1155/2014/608184)
    [Link] [pdf]
  3. Alan T. H. Lau, Hon Ming Yip, Kathy C. C. Ng, Xin Cui, and Raymond H. W. Lam, "Dynamics of Microvalve Operations in Integrated Microfluidics", Micromachines, vol. 5(1), pp. 50-65, 2014. (DOI: 10.3390/mi5010050)
    [Link] [pdf]

2013

  1. Min-Cheol Kim*, Raymond H. W. Lam*, Todd Thorsen, and H. Harry Asada, "Mathematical Analysis of Oxygen Transfer through Polydimethylsiloxane Membrane between Double Layers of Cell Culture Channel and Gas Chamber in Microfluidic Oxygenator", Microfluidics and Nanofluidics, vol. 15(3), pp. 285-296, 2013. (DOI: 10.1007/s10404-013-1142-8)
    [Link] [pdf]
  2. Weiqiang Chen, Nien-Tsu Huang, Boram Oh, Raymond H. W. Lam, Rong Fan, Timothy T. Cornell, Thomas P. Shanley, Katsuo Kurabayashi, and Jianping Fu, "Surface-Micromachined Microfiltration Membranes for Efficient Isolation and Functional Immunophenotyping of Subpopulations of Immune Cells", Advanced Healthcare Materials, vol. 2(7), pp. 965-975, 2013. (DOI: 10.1002/adhm.201200378)
    [Link] [pdf]
    - Selected as the front cover image.

  3. Weiqiang Chen, Shinuo Weng, Steven Allen, Xiang Li, Liwei Bao, Raymond H. W. Lam, Jill A. Macoska, Sofia D. Merajver, and Jianping Fu, "Nanoroughened Surfaces for Efficient Capture of Circulating Tumor Cells without Using Capture Antibodies", ACS Nano, vol. 7(1), pp. 566-575, 2013. (DOI: 10.1021/nn304719q)
    [Link] [pdf]
    -- Highlighted by C&EN Online Story (Link).
    - Selected as the front cover image.

2012

  1. Raymond H. W. Lam, Shinuo Weng, Wei Lu, and Jianping Fu, "Live-Cell Subcellular Measurement of Cell Stiffness Using a Microengineered Stretchable Micropost Array Membrane", Integrative Biology, vol. 4(10), pp. 1289-1298, 2012. (DOI: 10.1039/C2IB20134H)
    [Link] [pdf]
  2. Yubing Sun, Luis G Villa-Diaz, Raymond H. W. Lam, Weiqiang Chen, Paul H. Krebsbach, and Jianping Fu, "Matrix Mechanics Regulates Fate Decisions of Human Embryonic Stem Cells", PLoS ONE, vol. 7(5), e37178, 2012. (DOI: 10.1371/journal.pone.0037178)
    [Link] [pdf]
    -- Highlighted by ESC & iPSC News (Link).
  3. Denvid Lau, and Raymond H. W. Lam, "Atomistic Prediction of Nanomaterials: Introduction to Molecular Dynamics Simulation and a Case Study of Graphene Wettability", IEEE Nanotechnology Magazine, vol. 6(1), pp. 8-13, 2012. (DOI: 10.1109/MNANO.2011.2181739)
    [Link] [pdf]
  4. Weiqiang Chen, Luis G Villa-Diaz, Yubing Sun, Shinuo Weng, Jin koo Kim, Raymond H. W. Lam, Lin Han, Rong Fan, Paul H. Krebsbach, and Jianping Fu, "Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells", ACS Nano, vol. 6(5), pp. 4094-4103, 2012. (DOI: 10.1021/nn3004923)
    [Link] [pdf]
    -- Highlighted by ESC & iPSC News (Link) and C&EN Online Story (Link).
  5. Raymond H. W. Lam, Yubing Sun, Weiqiang Chen, and Jianping Fu, "Elastomeric Microposts Integrated into Microfluidics for Flow-Mediated Endothelial Mechanotransduction Analysis", Lab on a Chip, vol. 12(10), pp. 1865-1873, 2012. (DOI: 10.1039/C2LC21146G)
    [Link] [pdf]
    -- Selected as the Virtual Journal of Biological Physics Research, vol. 23(9), Instrumentation Development, 2012 (Link).
  6. Raymond H. W. Lam, and Wen J. Li, "A Digitally Controllable Polymer-based Microfluidic Mixing Module Array", Micromachines, vol. 3(2), pp. 279-294, 2012. (DOI: 10.3390/mi3020279)
    [Link] [pdf]
  7. Jennifer Mann*, Raymond H. W. Lam*, Shinuo Weng, Yubing Sun, and Jianping Fu, "A Silicone-Based Stretchable Micropost Array Membrane for Monitoring Live-Cell Subcellular Cytoskeletal Response", Lab on a Chip, vol. 12(4), pp. 731-740, 2012. (DOI: 10.1039/C2LC20896B)
    [Link] [pdf]
    -- Selected as one of the Lab on a Chip Top 10% articles (Link).
  8. Weiqiang Chen, Raymond H. W. Lam, and Jianping Fu, "Photolithographic Surface Micromachining of Polydimethylsiloxane (PDMS)", Lab on a Chip, vol. 12(2), pp. 391-395, 2012. (DOI: 10.1039/C1LC20721K)
    [Link] [pdf]
    -- Selected as the Virtual Journal of Nanoscale Science & Technology, vol. 25(2), Microfluidics and Nanofluidics, 2012 (Link).

2011 and earlier

  1. Raymond H. W. Lam, Min-Cheol Kim, and Todd Thorsen, "Culturing Aerobic and Anaerobic Bacteria and Mammalian Cells with a Microfluidic Differential Oxygenator", Analytical Chemistry, vol. 81(14), pp. 5918-5924, 2009. (DOI: 10.1021/ac9006864)
    [Link] [pdf]
  2. Min-Cheol Kim, Zhanhui Wang, Raymond H. W. Lam, and Todd Thorsen, "Building a Better Cell Trap: Applying Lagrangian Modeling to the Design of Microfluidic Devices for Cell Biology", Journal of Applied Physics, vol. 103(4), 044701, 2008. (DOI: 10.1063/1.2840059)
    [Link] [pdf]
    -- Selected as the Virtual Journal of Biological Physics Research, vol. 15(5), Physical Studies of Cell Mechanics, 2008 (Link).
 
  Conference Preceedings  
 
  1. Shuhuan Hu, and Raymond H. W. Lam, "Cell behaviors mediated by the scale of extracellular matrix micro-islands", Proceedings of the 10th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED), Macau, March, 2017.
    [Link]
  2. Chengpeng Yang, Vincent W. T. Li, K. N. Peter, S. H. Cheng, Raymond H. W. Lam, "Measurement of radiation based on amperometric activity of bacteria focused electrokinectically in microfluidics", Proceedings of the 10th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED), Macau, March, 2017.
    [Link]
  3. Baoce Sun, and Raymond H. W. Lam, "Influence of Micro-scale Substrate Curvature on Subcellular Behaviors of Vascular Cells", Proceedings of the 16th IEEE International Conference on Nanotechnology (NANO), Sendai, China, August 2016.
    [Link]
  4. Yohannes Lim Yaphary, Shuhuan Hu, Denvid Lau, and Raymond H. W. Lam, "Piezoelectricity of Portland Cement Hydrates Cured Under the Influence of Electric Field", Proceedings of the 16th IEEE International Conference on Nanotechnology (NANO), Sendai, China, August 2016.
    [Link]
  5. Yohannes L. Yaphary, Raymond H. W. Lam, Denvid Lau, "Chemical technologies for modern concrete production", Proceedings of the 12th Modern Building Materials, Structures and Techniques (MBMST), Vilnius, Lithuania, May 2016.
    [Link]
  6. Ya Liu, Xin Cui and Raymond H. W. Lam, "Cytokine profiling of lymphocytes using mixing-assisted functionalized microbead detection in microfluidics", Proceedings of the International Conference of Microfluidics, Nanofluidics and Lab-on-a-Chip, Dalian, China, Jun 2016.
    [Link]
  7. Xin Cui, and Raymond H. W. Lam, "A Microfluidic Long-Term Bacteria Culture Device with Controllable Humidity and Dissolved Oxygen" Proceedings of the 13th IEEE International Conference on Nanotechnology (NANO), Beijing, China, August 2013. (DOI: 10.1109/NANO.2013.6720859)
    [Link]
  8. Raymond H. W. Lam, "Measurement of heterogeneity in subcellular live-cell rigidity using a stretchable micropost array platform", Proceedings of the 6th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED), Bangkok, Thailand, November 2012. (DOI: 10.1109/NANOMED.2012.6509140)
    [Link]
  9. Yubing Sun, Luis G. Villa-Diaz, Raymond H. W. Lam, Weiqiang Chen, Paul H. Krebsbach, and Jianping Fu, "Micromechanical elastomeric devices for investigations of mechanobiology in human embryonic stem cells", Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2012), Okinawa, Japan, October 2012.
    [Link]
  10. Jennifer Mann, Raymond H. W. Lam, Shinuo Weng, Yubing Sun, and Jianping Fu, "A Microengineered Stretching Platform for Live-Cell Mechanotransductive Response Analysis" (Oral Presentation), Proceedings of the 15th International Conference on Miniaturized Systems for Chemistry & Life Sciences (µTAS 2011), Washington, USA, October 2011.
    [Link]
  11. Raymond H. W. Lam, Min-Cheol Kim, and Todd Thorsen, "A Microfluidic Oxygenator for Biological Cell Culture" (Oral Presentation), Proceedings of the 14th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2007), Lyon, France, June 2007. (DOI: 10.1109/SENSOR.2007.4300676)
    [Link]
  12. Min-Cheol Kim, Zhanhui Wang, Raymond H. W. Lam, and Todd Thorsen, "Simulation on Biological Cell Transport in the Microfluidic Devices", Proceedings of the NSTI Nanotechnology Conference and Trade Show (Nanotech 2007), California, USA, May 2007. (ISBN: 1-4200-6184-4)
    [Link]
  13. Raymond H. W. Lam, Miao Lei, Zaili Dong, Kin Fong Lei, and Wen J. Li, "Integrated Vortex Micropumps and Active Micromixers in Polymer Substrates for Automating Bio-fluidic Manipulation", Proceedings of the 27th Annual International Conference of the IEEE Engineering In Medicine and Biology Society, Shanghai, China, September 2005. (DOI: 10.1109/IEMBS.2005.1616664)
    [Link]
  14. Raymond H. W. Lam, Kin Fong Lei, Lei Miao, Zaili Dong, Wing Cheung Law, Yick Keung Suen, Wen J. Li, Aaron Ho Pu Ho, and Siu-Kai Kong, "Towards Automating Micro Cellular Detection Process Using Micro Vortex Pump Arrays", Proceedings of IEEE/ASME International Conference on Advanced Intelligent Mechatronics, California, USA, July 2005. (DOI: 10.1109/AIM.2005.1500967)
    [Link]
  15. Kin Fong Lei, Raymond H. W. Lam, Josh H. M. Lam, and Wen J. Li, "Polymer-based Vortex Micropump Fabricated by Micro Molding Replication Technique", Proceedings of IEEE/RSJ International Conference on Intelligent Robots and Systems 2004, Japan, September 2004. (DOI: 10.1109/IROS.2004.1389647)
    [Link]
  16. Raymond H. W. Lam, Josh H. M. Lam, Kin Fong Lei, and Wen J. Li, "Digitally Controllable Large-Scale Integrated Microfluidic Systems", Proceedings of IEEE International Conference on Robotics and Biomimetics, Shenyang, China, August 2004. (DOI: 10.1109/ROBIO.2004.1521794)
    [Link]
  17. Josh H. M. Lam, Raymond H. W. Lam, Kin Fong Lei, Winnie W. Y. Chow, and Wen J. Li, "A Polymer-based Microfluidic Mixing System Driven by Vortex Micropumps", Proceedings of the 5th World Congress on Intelligent Control and Automation, Hangzhou, China, June 2004. (DOI: 10.1109/WCICA.2004.1343812)
    [Link]
  18. Davey T. W. Fong, Joe C. Y. Wong, Alan H. F. Lam, Raymond H. W. Lam, and Wen J. Li, "A Wireless Motion Sensing System Using ADXL MEMS Accelerometers for Sports Science Applications", Proceedings of the 5th World Congress on Intelligent Control and Automation, Hangzhou, China, June 2004. (DOI: 10.1109/WCICA.2004.1343815)
    [Link]
  19. Alan H. F. Lam, Raymond H. W. Lam, Wen J. Li, Martin Y. Y. Leung, and Yunhui Liu, "Motion sensing for robot hands using MIDS", Proceedings of IEEE International Conference on Robotics and Automation (ICRA) 2003, Taipei, Taiwan, September 2003. (DOI: 10.1109/ROBOT.2003.1242080)
    [Link]
  20. Raymond H. W. Lam, and Wen J. Li, "A Wireless Temperature Measurement Guide Rod for Internal Bone Fixation Surgery", Proceedings of IEEE International Conference on Robotics and Automation (ICRA) 2003, Taipei, Taiwan, September 2003. (DOI: 10.1109/ROBOT.2003.1241850)
    [Link]
  21. Raymond H. W. Lam, Imad Elhajj, Wen J. Li, and Ning Xi, "A Bone Reaming System with Tactile Temperature Display", Proceedings of the 15th IFAC World Congress 2002, Barcelona, Spain, July, 2002. (DOI: 10.3182/20020721-6-ES-1901.00826)
    [Link]
  22. Raymond H. W. Lam, Imad Elhajj, Wen J. Li, and Ning Xi, "A Guide-Rod with Internet-based Temperature Sensation Display System for Bone Internal Fixation Surgery", Proceedings of International Conference on Control and Automation (ICCA 2002), Xiamen, China, June 2002. (DOI: 10.1109/ICCA.2002.1229389)
    [Link]
 

 

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Laboratory of Advanced Microfluidic Systems | Department of Mechanical and Biomedical Engineering | City University of Hong Kong
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